Publications

2016 onwards

  • Sruthi S. Balakrishnan, Urbashi Basu, Dhananjay Shinde, Rajan Thakur, Manish Jaiswal, Padinjat Raghu. Regulation of PI4P levels by PI4KIIIα during G-protein coupled PLC signaling in Drosophila photoreceptors.  J Cell Sci 2018 : jcs.217257 doi: 10.1242/jcs.217257

  • Sudipta Ashe Vivek Malhotra and Raghu, P. Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide.
    Dev.Biol. 2017. doi.org/10.1016/j.ydbio.2017.12.008

  • Shweta Yadav, Rajan Thakur, Plamen Georgiev, Deivasigamani S, Harini.K, Girish Ratnaparkhi and Raghu P. FFAT/VAP interaction imposes intramolecular regulation on lipid transfer function at membrane contact sites. J.Cell.Sci.2017,jcs.207985 doi: 10.1242/jcs.207985 

  •  Kamalesh Kumari, Deepti Trivedi, Sarah Toscano and ­­­Raghu P. Phosphatidylinositol 5-phosphate 4-kinase regulates clathrin mediated endocytosis in developing Drosophila photoreceptors.  J. Cell Sci. 2017 May 15. pii: jcs.202259. doi: 10.1242/jcs.202259. [Epub ahead of print]

  •  Thakur R, Panda A, Coessens E, Raj N, Yadav S, Balakrishnan S, Zhang Q, Georgiev P, Basak B, Pasricha R, Wakelam MJ, Ktistakis NT, Raghu P. Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling. Elife. 2016 Nov 16;5. pii: e18515. doi: 10.7554/eLife.18515. PubMed PMID: 27848911; PubMed Central PMCID: PMC5125754.

  •  Cockcroft S, Raghu P. Topological organisation of the phosphatidylinositol 4,5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER-PM gap. Biochem J. 2016 Dec 1;473(23):4289-4310. Review. PubMed PMID: 27888240.

  •  Cockcroft S, Garner K, Yadav S, Gomez-Espinoza E, Raghu P. RdgBα reciprocally transfers PA and PI at ER-PM contact sites to maintain PI(4,5)P2 homoeostasis during phospholipase C signalling in Drosophila photoreceptors. Biochem Soc Trans. 2016 Feb;44(1):286-92. doi: 10.1042/BST20150228. Review. PubMed PMID: 26862217.

  • Yadav S, Cockcroft S, Raghu P. The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites. Biochem Soc Trans. 2016 Apr 15;44(2):447-51. doi: 10.1042/BST20150256. Review. PubMed PMID: 27068953.

  •  Kolay S, Basu U, Raghu P. Control of diverse subcellular processes by a single multi-functional lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. Biochem J. 2016 Jun 15;473(12):1681-92. doi: 10.1042/BCJ20160069. Review. PubMed PMID: 27288030.

  • Choudhury SD, Mushtaq Z, Reddy-Alla S, Balakrishnan SS, Thakur RS, Krishnan KS, Raghu P, Ramaswami M, Kumar V. σ2-Adaptin Facilitates Basal Synaptic Transmission and Is Required for Regenerating Endo-Exo Cycling Pool Under High-Frequency Nerve Stimulation in Drosophila. Genetics. 2016 May;203(1):369-85. doi: 10.1534/genetics.115.183863. PubMed PMID: 26920756; PubMed Central PMCID: PMC4858786.

2011-2015

  1.  Yadav, S., Garner, K., Georgiev, P., Li, M., Gomez Espinosa, E., Panda, A., Mathre, M., Cockcroft, S and Raghu, P. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction. J.Cell.Sci. 2015 128:3330-3344

  2. Chakrabarti, P., Kolay, S., Yadav, S, Kamalesh Kumari, K., Nair, A., Trivedi, D and Raghu, P. A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors. PLOS Genetics. 2015

  3. Balakrishnan SS, Basu U, Raghu P. Phosphoinositide signalling in Drosophila. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 2014 Oct 30. pii: S1388-1981(14)00219-4

  4. Lowe, N, Rees, J and the UK Drosophila Protein Trap Screening Consortium*. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Development (2014) 141, 3994-4005.
    *Raghu P member of Consortium.

  5. Gupta, A, Sarah Toscano, S, Trivedi, D, Jones DJ, Mathre S, Clarke J, Georgiev P, Divecha N and Raghu P. (2013) Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signalling and cell growth during Drosophila development.(Proc.Natl.Acad.Sci.USA published ahead of print March 25, 2013, doi:10.1073/pnas.1219333110).

  6. Chu B, Liu CH, Sengupta S, Gupta A, Raghu P, Hardie RC. (2013) Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors. J Neurophysiol. 2013 Jan 30. [Epub ahead of print].

  7.  Badsha F, Kain P, Prabhakar S, Sundaram S, Raghu P, Rodrigues V, Hasan G. (2012) Mutants in Drosophila TRPC Channels Reduce Olfactory Sensitivity to Carbon Dioxide. PLoS One. 2012; 7(11): e49848.

  8. Garner K, Hunt AN, Koster G, Somerharju P, Groves E, Li M, Raghu P, Holic R, Cockcroft S. (2012) Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers Phosphatidic Acid. J.Biol.Chem. Sep 14; 287(38): 32263-7.

  9. Georgiev P, Toscano S, Nair A, Hardie R, Raghu P. (2012) Identification of a suppressor of retinal degeneration in Drosophila photoreceptors. J. Neurogenet. Sep 26 (3-4): 338-47.

  10. Raghu, P., Yadav, S and Mallampati, N. (2012) Lipid signalling in Drosophila photoreceptors. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. Vesicular Transport. 1821(8):1154-65.


    2006-2010

  11. Georgiev, P., Okkenhaug, H, Drews, A, Wright, D., Flick, M, Lambert, S, Oberwinkler, J and Raghu, P (2010). TRPM channels mediate zinc homeostasis and cellular growth during Drosophila larval development. Cell Metabolism. 12, 386–397

  12. Dolph, P, Nair, A and Raghu, P. (2010) Analysis of visual physiology in the adult Drosophila eye. Book chapter in Drosophila Neurobiology Methods: A Laboratory Manual. Cold Spring Harbor Laboratory Press. Chapter 14. 225-235.

  13. Raghu, P, Coessens E, Manifava M, Georgiev P, Pettitt T, Wood E, Garcia-Murillas I, Okkenhaug H, Trivedi D, Zhang Q, Razzaq A, Zaid O, Wakelam MJO, O'Kane CJ, Ktistakis NT (2009) Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels. Journal of Cell Biology 185 129-145.

  14. Raghu P, Hardie RC. 2009 Regulation of Drosophila TRPC channels by lipid messengers. Cell Calcium. 45(6):566-73.

  15. Raghu, P, Manifava M, Coadwell WJ, Ktistakis NT. 2009 Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors). Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1791(9):889-97

  16. Trivedi D and Raghu P. RdgB proteins; functions in lipid homeostasis and signal transduction. BBA; Molecular and Cell Biology of Lipids. (2007). 1771:692-699.


  17. Raghu, P. Regulation of Drosophila TRPC channels by protein and lipid interactions. Semin Cell Dev Biol (2006). 17(6):646-653

  18. Garcia-Murillas I, Pettit T, Macdonald E, Okkenhaug H, Georgiev P, Trivedi D, Hassan B, Wakelam M and Raghu, P (2006) Iazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Neuron. 29:4, 533-546.

  19. Georgiev, P, Garcia-Murillas, I, Ulahannan, D Hardie, R.C and Raghu, P. (2005) Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.”  J.Cell.Sci. 118:1373-1384

  20. Raghu, P. LPP2. AfCS-Nature Molecule Pages (2005). doi:10.1038/mp.a003072.0

    2001-2005

  21. Raghu, P and Andrews, S (2004) TRP channels at a glance. J.Cell.Sci. 117:5707-5709

  22. Hardie, R.C, Gu, Y., Martin, M., Sweeney,S.T and Raghu, P.(2004) In Vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1) J. Biol. Chem. 279: 47773 – 47782

  23. Hardie, RC, Martin F, Chyb S and Raghu, P. Rescue of light responses in the Drosophila "null” phospholipase C mutant, norpAP24 by diacylglycerol kinase mutant, rdgA and by metabolic inhibition. J. Biol. Chem. 2003; 278: 18851 – 18858.

  24. Hardie, R.C., Martin, F., Cochrane, G.R., Jussola, M.G, Georgiev, P & Raghu, P. (2002) Molecular basis of amplification in Drosophila phototransduction: roles for G-protein, phospholipase C and diacylglycerol kinase. Neuron. 36: 689-701.

  25. Hardie, R.C. & Raghu, P. (2001) Visual transduction in Drosophila. Nature. 413:186-193.

  26. Hardie, R.C, Raghu, P, Moore, S, et.al, (2001) Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron. 30: 1-20.

    1995-2000

  27. Raghu, P, Usher, K.R, Jonas, J, et.al, (2000) Constitutive activity of the light sensitive channels, TRP and TRPL, in the Drosophila diacylglycerol kinase mutant, retinal degeneration A (rdgA) ). Neuron. 26: 169-179.

  28. Raghu, P, Colley,N.J, Webel, R., et.al, (2000) Normal phototransduction in Drosophila photoreceptors lacking an InsP3 receptor. Mol. Cell. Neurosci. 15: 429-445.

  29. Chyb, S, Raghu, P & Hardie, R.C. (1999) Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature. 397: 255-259

  30. Hardie, R.C. & Raghu, P. (1998) Activation of heterologously expressed Drosophila TRPL channels: Ca2+ is not required and InsP3 is not sufficient. Cell Calcium. 24(2): 153-163.

  31. Raghu, P., Habib, S., Hasnain, E. & Hasan, G. (1996) Development of a functional assay for Ca2+ release activity of IP3R and expression of an IP3R gene fragment in the baculovirus-insect cell system. Gene. 190:151-156.

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